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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCB1 All Species: 53.03
Human Site: S1210 Identified Species: 97.22
UniProt: P08183 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08183 NP_000918.2 1280 141479 S1210 T S A L D T E S E K V V Q E A
Chimpanzee Pan troglodytes XP_519183 1280 141455 S1210 T S A L D T E S E K V V Q E A
Rhesus Macaque Macaca mulatta NP_001028059 1283 141504 S1213 T S A L D T E S E K V V Q E A
Dog Lupus familis XP_539461 1269 140189 S1202 T S A L D N E S E K V V Q H A
Cat Felis silvestris
Mouse Mus musculus P21447 1276 140628 S1206 T S A L D T E S E K V V Q E A
Rat Rattus norvegicus P43245 1277 141369 S1209 T S A L D T E S E K V V Q E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508941 1368 147746 S1298 T S A L D T E S E K L V Q D A
Chicken Gallus gallus XP_418636 1307 144961 S1237 T S A L D T E S E K I V Q E A
Frog Xenopus laevis NP_001081394 1287 141487 S1219 T S A L D T E S E K V V Q E A
Zebra Danio Brachydanio rerio XP_001922717 1340 147081 S1272 T S A L D T E S E K I V Q A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q00748 1302 143766 S1235 T S A L D L Q S E Q L V Q Q A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34712 1321 145045 S1252 T S A L D T E S E K V V Q E A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O80725 1286 139009 S1216 T S A L D A E S E R V V Q D A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96 55.7 N.A. 87.1 80.6 N.A. 62.1 69.6 67.6 56 N.A. 41.1 N.A. 44.5 N.A.
Protein Similarity: 100 99.8 97.7 75.4 N.A. 93.3 90.1 N.A. 76.6 83.6 81.8 73.5 N.A. 60.4 N.A. 62.6 N.A.
P-Site Identity: 100 100 100 86.6 N.A. 100 100 N.A. 86.6 93.3 100 86.6 N.A. 66.6 N.A. 100 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 100 100 N.A. 100 100 100 93.3 N.A. 93.3 N.A. 100 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 41.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 62.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 80 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 100 0 0 8 0 0 0 0 0 0 0 8 100 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 100 0 0 0 0 0 0 0 0 16 0 % D
% Glu: 0 0 0 0 0 0 93 0 100 0 0 0 0 62 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 16 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 85 0 0 0 0 0 % K
% Leu: 0 0 0 100 0 8 0 0 0 0 16 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 8 0 0 8 0 0 100 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 100 0 0 0 0 0 100 0 0 0 0 0 0 0 % S
% Thr: 100 0 0 0 0 77 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 70 100 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _